Amadine sagety6/11/2023 ![]() Maximum plasma concentrations are directly related to dose for doses up to 200 mg/day. Although amantadine has not been shown to possess direct anticholinergic activity in animal studies, clinically, it exhibits anticholinergic-like side effects such as dry mouth, urinary retention, and constipation.Īmantadine hydrochloride is well absorbed orally. More recent studies have demonstrated that amantadine is a weak, non-competitive NMDA receptor antagonist (K i = 10μM). Data from earlier animal studies suggest that amantadine hydrochloride may have direct and indirect effects on dopamine neurons. The mechanism of action of amantadine hydrochloride in the treatment of Parkinson's disease and drug induced extrapyramidal reactions is not known. The quantitative relationship between the in vitro sensitivity of influenza A variants to amantadine and the clinical response to therapy has not been established. Influenza viruses with reduced in vitro sensitivity have been shown to be transmissible and to cause typical influenza illness. Influenza A variants with reduced in vitro sensitivity to amantadine have been isolated from epidemic strains in areas where adamantane derivatives are being used. Host cells in tissue culture readily tolerated amantadine up to a concentration of 100 mcg/mL. (ED 50) in tissue culture vary greatly (from 0.1 mcg/mL to 25 mcg/mL) depending upon the assay protocol used, size of virus inoculum, isolates of influenza A virus strains tested, and the cell type used. Sensitivity test results, expressed as the concentration of amantadine required to inhibit by 50% the growth of virus A quantitative relationship between the in vitro susceptibility of influenza A virus to amantadine and the clinical response to therapy has not been established in man. It has very little or no activity against influenza B virus isolates. It does not appear to interfere with the immunogenicity of inactivated influenza A virus vaccine.Īmantadine inhibits the replication of influenza A virus isolates from each of the subtypes, i.e., H1N1, H2N2 and H3N2. In certain cases, amantadine is also known to prevent virus assembly during virus replication. It appears to mainly prevent the release of infectious viral nucleic acid into the host cell by interfering with the function of the transmembrane domain of the viral M2 protein. The mechanism by which amantadine exerts its antiviral activity is not clearly understood. Amantadine Tablets - Clinical Pharmacology ![]() AMANTADINE HYDROCHLORIDE - amantadine hydrochloride tabletĪmantadine hydrochloride is designated generically as amantadine hydrochloride and chemically as 1- adamantanamine hydrochloride.Īmantadine hydrochloride is a stable white or nearly white crystalline powder, freely soluble in water and soluble in alcohol and in chloroform.Īmantadine hydrochloride has pharmacological actions as both an anti-Parkinson and an antiviral drug.Įach tablet intended for oral administration contains 100 mg amantadine hydrochloride and has the following inactive ingredients: microcrystalline cellulose, povidone, sodium starch glycolate, magnesium stearate, colloidal silicon dioxide, FD&C Yellow No.
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